580 INCIDENCE AND FACTORS ASSOCIATED WITH DE NOVO ATRIAL FIBRILLATION IN PATIENTS WITH WILD-TYPE TRANSTHYRETIN CARDIAC AMYLOIDOSIS - A MULTICENTER STUDY
نویسندگان
چکیده
Abstract Purpose We described the incidence and ECG factors associated with de novo atrial fibrillation (AF) in patients diagnosed wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) to drive tailored arrhythmia screening. Background Data on rate AF ATTRwt CA is limited. Methods Multicenter, retrospective, observational cohort study performed six referral centers for CA. All consecutive ATTRwt-CA between 2004 2020 >1-year follow up (FU) were enrolled divided into three groups according presence of AF: (1)patients ‘known AF’; (2)patients ‘sinus rhythm’ (3)patients developing ‘de AF’ during FU. Incidence primary outcomes. Results Overall, 266 followed a median 469 days: 148 (56%) known AF, 84 (31.6%) sinus rhythm, 34 (12.8%) AF. Age gender similarly distributed. At multivariable analysis, PR (Hazard Ratio[HR]: 1.008 95% C.I. 1.001-1.016), QRS (HR: 1.022 1.002-1.043) left dilatation>50mm 3.429 1.565-7.329) at Patients presenting least two risk (PR>200ms, QRS>120ms or LAD>50mm) had higher compared no (HR 14.918 3.242-31.646). Conclusions 20.7%/year. Longer duration dilation are onset.
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Results Comparison of clinical findings between males and females affected by wt-ATTR amyloidosis are shown in table 1. Female patients with wt-ATTR did not differ from male patients regarding demographic or clinical parameters except for modified body mass index (1140±184 vs. 1029±154, p<0.05), glomerular filtration rate (66±23 vs. 85±31 ml/min*m*1.73; p<0.05), NYHA class (2.4±0.7 vs. 2.9±0.3;...
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2022
ISSN: ['1520-765X', '1554-2815']
DOI: https://doi.org/10.1093/eurheartjsupp/suac121.618